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Vitamin D and neurology : ウィキペディア英語版 | Vitamin D and neurology
Vitamin D is a steroid hormone that plays a vital role in calcium and phosphate absorption. In recent studies, several associations between low levels of vitamin D, or hypovitaminosis D, and neuropsychiatric disorders have begun to surface.〔Harms, L. R., Burne, T. H. J., Eyles, D. W., & McGrath, J. J. (2011). Vitamin D and the brain. Best practice & research. Clinical endocrinology & metabolism, 25(4), 657-69. Elsevier Ltd. doi:10.1016/j.beem.2011.05.009〕 These disorders include, but are not limited to: Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and schizophrenia.〔 ==Physiology==
Vitamin D is mainly found in the body in two forms: vitamin D3 and vitamin D2. Vitamin D3, or cholecalciferol, is formed in the skin after exposure to sunlight or ultra violet radiation. Vitamin D2, or ergocalciferol, is obtained from various food sources including milk and fish.〔Lips, P. (2006). Vitamin D physiology. Progress in biophysics and molecular biology, 92(1), 4-8. doi:10.1016/j.pbiomolbio.2006.02.016〕 These two forms of vitamin D are metabolized in the liver and stored as 25-hydroxyvitamin D.〔Christakos, S., Ajibade, D.V., Dhawan, P., Fechner, A. J., Mady, L.J. (2011). NIH Public Access. Endocrinology And Metabolism, 39(2), 243-253. doi:10.1016/j.ecl.2010.02.002.Vitamin〕 Before biological use, the storage form must be converted into an active form. One common active form is 1,25 dihydroxyvitamin D.〔 The term ''vitamin D'' in this article, refers to group of molecules including cholecalciferol,ergocalciferol, 25-hydroxyvitamin D, and the active forms. The role of vitamin D is best characterized as enabling calcium absorption and regulating calcium homeostasis. Vitamin D also play a role in phosphate absorption.〔Harvey, M. (2012, October 17). Interview by TN Smith (Tape Recording ). Vitamin d and neuropsychiatric disorders〕
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